Research+
SECTION TWO
RESEARCH+
We'll soon get to ways we may be able to have ourselves be among those who will be able to choose any desired lifespan while living in perfect health. First, however, let's take a look at some of the actual relevant research going on today.
Reader's note: To maintain total authenticity the links are all in their original form, despite the fact that current vogue is to abbreviate them. An excerpt (or excerpts) from each article follows its link.
TISSUE ENGINEERING
http://www.newsweek.com/future-medicine-growing-new-organs-69037It might sound like science fiction, but growing new organs from scratch has already become reality. In addition to bladders, scientists have engineered new skin, bone, cartilage, corneas, windpipes, arteries, and urethras..
STEM CELLS
Scientists may one day slow down aging with a simple injection of youthful stem cells. They've just proven this can be done in mice, according to a study published Tuesday in Nature Communications.
IPS -- Induced pluripotent stem cells
IPS -- Induced pluripotent stem cells
[The two scientists were 2012 Nobel prize winners.]..Taken together, Gurdon's and Yamanaka's discoveries have turned fundamental biological concepts on their head. Their experiments prove that every cell, whether young or old, in embryos or in adults, has a similar ability to reprogram itself to become a young again, and thus capable of becoming any cell in the body.
THE HUMAN GENOME PROJECT
THE HUMAN GENOME PROJECT
Dr. Kim said that having the genome sequence gave scientists the ability to do science at a different level. At Genentech, one-third of the drugs in clinical trials and two-thirds of the newer compounds earlier in development have been enabled in a significant way by the genome project, said Marc Tessier-Lavigne, executive vice president for research at Genentech, a unit of Roche.
NANOTECHNOLOGY
NANOTECHNOLOGY
[Also alluded to in the previous section] Ray Kurzweil, world-renowned creator of many innovative devices“ the main inventor of the computer scanner and the music synthesizer: It'll [a computer] be the size of a blood cell. Within a couple of decades, we will have "nanobots" in our blood stream, basically small robots the size of blood cells, that will keep us healthy at the cellular and molecular level...These devices will be a billion times more powerful than they are today in 25 years, and will continue the accelerating path to radical life extension.....
TELOMERES
[University of Copenhagen website.]
In collaboration with an international research team, University of Copenhagen researchers have for the first time mapped telomerase, an enzyme which has a kind of rejuvenating effect on normal cell ageing. The findings have just been published in Nature Genetics .telomerase“ an enzyme capable of creating new ends on cellular chromosomes, the so-called telomeres. In other words, a kind of cellular fountain of youth.
SIRTUINS
SIRTUINS
We already know that sirtuins regulate aging, but our study is really the first one demonstrating that sirtuins can reverse aging-associated degeneration, and I think that's very exciting, said study principal investigator Danica Chen, UC Berkeley assistant professor of nutritional science and toxicology Studies have already shown that even a single gene mutation can lead to lifespan extension, said Chen Can we actually reverse aging? This is something we're hoping to understand and accomplish.
CRYONICS
http://www.huffingtonpost.com/entry/fully-intact-brain-frozen_us_56bb942ae4b0b40245c51654
.....a group of researchers successfully froze a rabbit brain [and brought it back].....
“This research is a first because it works on whole brains and preserves all of the synaptic details,he said. .....
Every neuron and synapse looks beautifully preserved across the entire brain. Simply amazing given that I held in my hand this very same brain when it was vitrified glassy solid, BPF president Dr. Kenneth Hayworth said in a statement. This is not your father's cryonics.
SUPERCOMPUTERS AND MECHANICS
When Robert B. Darnell was a graduate student in the early 1980s, he spent a year sequencing a tiny fragment of DNA...[Today] the DNA-sequencing machines can decode his grad-school fragment in less than a ten-thousandth of a second.
Note: To avoid repetition, "rejuvenation," "anti-aging," and similar terms will be used interchangeably with "health and life-extension." In addition, at times we'll use the abbreviation "Hale" for "health and life extension."
A deeper exposition of the advances explored is available (See end of page). But, as even the above examples help illustrate:
- Stem cell research and tissue engineering promise a real avenue for creation of new body parts. (As will be shown, some are already accomplished and working inside people.)
- Induced (created by gene manipulation of adult cells) pluripotent stem cells are expected to be commonly used for rejuvenation of diseased or deficient body parts and organs.
- Telomere research is showing how and why human cells age and die and how to stop them from doing so.
- Nanotechnologists are getting closer to producing blood cell-sized computers which will be able to go through the human body and repair it cell-by-cell.
- The completed Human Genome Project has already given us much of the blueprint to the "book of life" itself.
- Sirtuin studies may lead directly to drugs that increase lifespan, and could unlock secrets of age reversal.
- About 300 people including baseball great Ted Williams are currently cryogenically preserved. Chances of them being brought back intact are steadily improving.
- Supercomputers are exponentially year by year increasing our brainpower, expanding our ability to understand and master voluminous aspects of the aging process.
Many other areas of study leading to human healthful lifespan choice are underway. A few examples are: gene therapy (incorporating CRISPR), mitochondrial restoration (incorporating NAD), developmental inertia, studies of biologically immortal animals such as the Hydra, immunotherapy, the C1q protein, the precision medicine initiative, epigenetics, brain uploading.
In terms of further perspectives, it is worth looking at Aubrey de Grey's Sens Foundation and its anti-aging strategies and viewpoints. See: https://www.fightaging.org/archives/2013/03/why-prioritize-sens-research-for-human-longevity.php
While, as previously alluded to, nobody can perfectly predict the future, it's reasonable to say the furtherance of mentioned breakthroughs, as well as many others in various areas coming to fruition, will eventually lead to a perfect-health lifespan with choice of its length. Why should we, probably all of us, narrowly miss it? Again, we don't want that unfairness beyond measure to happen.
https://www.fightaging.org/archives/2013/03/why-prioritize-sens-research-for-human-longevity.php While, as previously alluded to, nobody can perfectly predict the future, it's reasonable to say the furtherance of mentioned breakthroughs, as well as many others in various areas coming to fruition, will eventually lead to a perfect-health lifespan with choice of its length. Why should we, probably all of us, narrowly miss it? Again, we don't want that unfairness beyond measure to happen.
There's no reason we couldn't, at the least, collectively make some real attempt to not all wind up stopped just short of the finish line. By the way, we don't necessarily need to have everything in place to be among those able to avail themselves of the benefits. If enough advances provide us with, say, fifty extra years of healthy life, during that fifty years enough advances could provide another hundred, and so on.
There is nothing natural about the pace of science. It is inherently unnatural. From an American perspective: We were on the moon eight years after we decided we needed to be; we had the atomic bomb in three years from nothing but a theory, because there we absolutely had to have it before those countries that were the enemy at the time did.
There is nothing natural about the pace of science. It is inherently unnatural. From an American perspective: We were on the moon eight years after we decided we needed to be; we had the atomic bomb in three years from nothing but a theory, because there we absolutely had to have it before those countries that were the enemy at the time did.
it's worth noting that scientists then predicted those accomplishments could and would happen. Many nation's accelerated scientific projects throughout history, as well as those of researchers from more than one place sharing technology when something had to be done, could provide other examples.
These projects took money and concerted work. Relative results would likely be achieved with many aging-control endeavors if the necessary funds were spent worldwide and the necessary effort and will were expended. It's certainly worth a try.
On the way we would greatly improve our ability to treat and cure all the diseases and degenerations that claim so many lives, and to greater or lesser degrees negatively affect the quality of so many more: diabetes, arthritis, heart disease, Crohn's disease, kidney failure, dementia, spinal conditions, AIDS, auto-immune disorders, cosmetic issues, blindness, malaria, sleep apnea, baldness, Barret's esophagus, acne, influenza, hepatitis, muscular dystrophy, syphilis, dental problems, cancer, peptic ulcers, typhus, etc., etc., etc.
Because health and lifespan discoveries cover the essences of medical malady, we should be able to, some sooner, some later, finally cure all diseases and infirmities. Once we realize that we all have the definite potential to be one of the healthy people who can live as long as they may desire to, methods for preservation and reanimation, like cryonics, could be vastly improved and made more affordable.
These projects took money and concerted work. Relative results would likely be achieved with many aging-control endeavors if the necessary funds were spent worldwide and the necessary effort and will were expended. It's certainly worth a try.
On the way we would greatly improve our ability to treat and cure all the diseases and degenerations that claim so many lives, and to greater or lesser degrees negatively affect the quality of so many more: diabetes, arthritis, heart disease, Crohn's disease, kidney failure, dementia, spinal conditions, AIDS, auto-immune disorders, cosmetic issues, blindness, malaria, sleep apnea, baldness, Barret's esophagus, acne, influenza, hepatitis, muscular dystrophy, syphilis, dental problems, cancer, peptic ulcers, typhus, etc., etc., etc.
Because health and lifespan discoveries cover the essences of medical malady, we should be able to, some sooner, some later, finally cure all diseases and infirmities. Once we realize that we all have the definite potential to be one of the healthy people who can live as long as they may desire to, methods for preservation and reanimation, like cryonics, could be vastly improved and made more affordable.
Then even those in later age could be included in the total fruition of anti-aging discoveries. In fact all modalities need to be made as available and affordable as soon as possible, like smallpox vaccine is today, so that all people, including the poorest in the poorest countries may benefit.
The best way to see to it that all the above goals are met is to first achieve a sufficient collective worldwide popular will in the needed direction, then to coalesce and exert that desire on the politicians, foundations, and other people and entities that are capable of accomplishing an immediate and massive infusion of funds into health-life extension research. (Scientists in all related fields say the only thing slowing them down is lack of funding.)
The best way to see to it that all the above goals are met is to first achieve a sufficient collective worldwide popular will in the needed direction, then to coalesce and exert that desire on the politicians, foundations, and other people and entities that are capable of accomplishing an immediate and massive infusion of funds into health-life extension research. (Scientists in all related fields say the only thing slowing them down is lack of funding.)
And, the best way to achieve all the above is by starting a huvement (pronounced "you've- ment," a movement that directly affects all of humanity). Like, but more comprehensive in effect than the American initiated civil-rights and feminist movements. (In fact in the last few years some successful movements have started such as "Black Lives Matter." It seems many other groups are now calling their projects a "movement." Why shouldn't health-life extensionists have a huvement?)
In fact, such a huvement has already begun. Besides of course the researchers and scientists themselves in universities and labs throughout the world, as stated a number of ardent organizations and individuals are working toward supporting the views typified above. These include: FightAging, Humanity+, The Life-Extension Foundation, Google's Calico, LongevityForAll, The Sens Foundation, Singularity University, Maxlife Foundation, Longecity, RAAD Fest, Coalition for Radical Life Extension. (For more on any or all see Links in the navigation buttons later, or click here now: Links .)
Links .) But the objectives of different groups are designated by each individually with various terms. Some describe their destination by one, some another, some still others. Terms such as "longevity," "health-extension," "immortality," life-extension," "health and life extension," "anti-aging," "aging control," "rejuvenation," and so on.
While essentially synonymous (as stated we use them interchangeably to describe a perfect-health indeterminate lifespan), no movement can be described by a number of different terms. Furthermore, the goals themselves of some groups are sometimes amorphous. Our huvement thus has little public recognition, no real name, and no coherent, central framework or coordination.
For a movement (or certainly a huvement) to progress it must have a single name and one clearly defined goal, or the public, which is crucial to its success, won't be able to follow or understand what it's about.
We've, it should be added, coined the word "huvement" to distinguish ourselves from societal-specific movements and from such projects as even commercial ad campaigns (e.g. ATT's "Mobile Movement") that use the word "movement" to inflate their actual reach. (The term "movement," while legitimately used by some groups, has become overused and diluted within the last few years.)
We've, it should be added, coined the word "huvement" to distinguish ourselves from societal-specific movements and from such projects as even commercial ad campaigns (e.g. ATT's "Mobile Movement") that use the word "movement" to inflate their actual reach. (The term "movement," while legitimately used by some groups, has become overused and diluted within the last few years.)
This website reflects (following a number of meetings and discussions) the creation and the start of a real and powerful huvement. We are calling it the Include-Everyone huvement for now, and until the actual movement's members are able to decide on a single name and goal for the huvement. We want to include everyone now alive in the present and coming Hale developments. Everyone! The old, the young, the rich, the poor, those in the large countries, those in the small countries, those in areas without clearly defined countries.
Our goal is to get enough people on board to attain the needed world-wide motivation to drive the idea that, via massive funding, relevant research is accelerated and made universally available so that we (everyone on the planet now alive and who will be alive) can benefit to the maximum extent from already-existent, and future, health and life extension advances.
So, inclusion of everyone in health and life extension, the control of aging, is the end point. The Include-Everyone huvement (or whatever it will finally be called) is the means by which we will get there.
We have already started (or are in the process of executing), information dissemination, establishing a political action committee, garnering publicity, creating sensible large demonstrations, and otherwise promoting pro health-life extension viewpoints, while organizing, coalescing, and coordinating all groups and individuals now already engaged in such and related endeavors.
Because people have been programmed to believe that aging and death are inevitable, most have a natural tendency to defend against new ideas on total longevity. The Include-Everyone huvement will deal with such questions as it works to enhance the public's perspectives.
As will be seen, questions such as what to do about "so many people" can be answered by developing new and sensible perspectives, while understanding how present and developing technologies in other areas can solve these problems.
Some years ago, on the TV program "Sixty Minutes," after commenting on the sheep cloning and what it showed about the general power of science, Andy Rooney said, "A friend of mine once said he was afraid he would die of cancer just before they discovered a cure for cancer. I'm afraid I'm going to die of death just before they discover a cure for death." (He did. Lets not have the same thing happen to us.)
Some years ago, on the TV program "Sixty Minutes," after commenting on the sheep cloning and what it showed about the general power of science, Andy Rooney said, "A friend of mine once said he was afraid he would die of cancer just before they discovered a cure for cancer. I'm afraid I'm going to die of death just before they discover a cure for death." (He did. Lets not have the same thing happen to us.)
END OF SECTION TWO -- RESEARCH +
Reader's note: Again, it's recommended you read the site's next two sections in order; each flows into the one following. You can, however, as stated, certainly navigate the parts in any way you wish. (With any web page, as you may already know, you can hold "control" and press "home" at any point in the page to return to the navigation buttons.)
If you want to (now or later) further and more fully explore any of the areas touched on above (stem cells, teleomeres, etc.) just go to the "Links" page and click on the appropriate "In Depth" link. Links
LinksIf, at any point you feel there's too much information or the like, take a break. The entire site doesn't have to be read in one sitting. To go directly to the next section click here: Objections